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Gene rearrangements in T‐cell lymphoblastic lymphoma
Author(s) -
Pilozzi Emanuela,
MüllerHermelink HansKonrad,
Falini Brunangelo,
de WolfPeeters Christine,
Fidler Carrie,
Gatter Kevin,
Wainscoat James
Publication year - 1999
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199907)188:3<267::aid-path357>3.0.co;2-n
Subject(s) - t cell receptor , gene rearrangement , cd3 , lymphoma , lymphoblastic lymphoma , lineage (genetic) , t cell , gene , immunoglobulin heavy chain , biology , cancer research , microbiology and biotechnology , immunology , genetics , antigen , cd8 , immune system
This study presents an examination of the Ig heavy chain (IgH) and T‐cell receptor gamma (TCRγ) genes in a series of 39 CD3‐positive T‐cell acute lymphoblastic leukaemia (ALL) cases with and without co‐expression of CD79a; 30/39 cases had a rearrangement of the TCRγ genes and two of these 30 cases also demonstrated an IgH rearrangement. No cases had solely an IgH rearrangement. The conclusion of the study is that lymphoblastic lymphoma cases that are positive for CD3 are of T‐cell lineage, regardless of CD79a expression. Copyright © 1999 John Wiley & Sons, Ltd.