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Oestrogen receptor and its potential role in breast cancer development
Author(s) -
Walker Rosemary A.
Publication year - 1999
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199907)188:3<229::aid-path341>3.0.co;2-f
Subject(s) - oestrogen receptor , breast cancer , cancer research , oncology , medicine , cancer , biology
The first studies of oestrogen receptor (ER) focused on measurements of levels in breast cancers and relationship to hormonal response, but the introduction of antibodies which can be used on fixed tissue has meant that ER can be studied in detail in normal and precancerous tissue. Cloning and sequencing of ER has resulted in more detailed understanding of structure and function, with the identification of variant forms in both tumours and normal, followed by the discovery that ER has two forms, the classical ER‐α and ER‐β. Analyses of both forms in normal and preneoplastic breast will be important for our understanding of the role of ER in the development of breast cancer and its possible prevention. Copyright © 1999 John Wiley & Sons, Ltd.