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Serrated adenoma and colorectal cancer
Author(s) -
Jass J. R.
Publication year - 1999
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199904)187:5<499::aid-path309>3.0.co;2-b
Subject(s) - microsatellite instability , hyperplastic polyp , colorectal cancer , phenotype , mucin , adenoma , gastrointestinal cancer , cancer research , biology , cancer , pathology , medicine , gastroenterology , genetics , microsatellite , gene , colonoscopy , allele
Hyperplastic polyps and serrated adenomas of the colorectum show mixed gastrointestinal differentiation, expressing both gastric (M1 or MUC5AC) and intestinal (MUC2) mucins. They also share the phenotype of mild DNA microsatellite instability (MSI‐L). Recent findings of clonal genetic changes within hyperplastic polyps fit with a pathway of serrated neoplasia, perhaps culminating in the subset of colorectal cancer characterized by the mild mutator phenotype. Copyright © 1999 John Wiley & Sons, Ltd.