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Interferon‐γ‐induced ICAM‐1 and CD40 expression, complete lack of HLA‐DR and CD80 (B7.1), and inconsistent HLA‐ABC expression in basal cell carcinoma: a possible role for interleukin‐10?
Author(s) -
Kooy Angela J. W.,
Prens Errol P.,
van Heukelum Alexander,
Vuzevski Voijslav D.,
van Joost Theodoor,
Tank Bhupendra
Publication year - 1999
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199902)187:3<351::aid-path227>3.0.co;2-6
Subject(s) - cd80 , cd40 , epidermis (zoology) , biology , major histocompatibility complex , hla dr , human leukocyte antigen , intercellular adhesion molecule 1 , immune system , microbiology and biotechnology , cancer research , immunology , antigen , cell adhesion molecule , cytotoxic t cell , in vitro , biochemistry , anatomy
Basal cell carcinomas (BCCs) of the skin show varying degrees of peritumoural inflammatory infiltrate consisting mainly of T cells, but lack an effective T‐cell‐mediated immune response. This may be caused by the absence of the major histocompatibility complex (MHC) class I and II antigens, intercellular adhesion molecule‐1 (ICAM‐1), CD40 and CD80 (B7.1). Interferon‐γ(IFN‐γ) is known to induce or up‐regulate their expression on epithelial cells, whereas interleukin‐10 (IL‐10) down‐regulates their expression. The induction and up‐regulation of HLA‐ABC, HLA‐DR, ICAM‐1, CD40, and CD80 in BCC and normal skin from BCC patients were investigated in a culture system using recombinant human IFN‐γ (rHuIFN‐γ). The levels of IL‐10 were determined in the supernatants after culture. The results showed that only ICAM‐1 expression was significantly up‐regulated on BCC cells. However, in the normal epidermis of BCC patients and in the epidermis overlying the tumour nests, significant up‐regulation of ICAM‐1, CD40, and CD80 and slight up‐regulation of HLA‐DR were observed. No changes in HLA‐ABC expression were observed in either normal skin or BCC. High levels of IL‐10 were present in the supernatants of BCC biopsies after culture. It may be concluded that it is highly likely that the presence of IL‐10 in BCC is directly or indirectly responsible for the complete lack of expression of HLA‐DR, ICAM‐1, CD40 and CD80 and the inconsistent expression of HLA‐ABC on BCC cells in situ and may be a way of escaping immune surveillance. Copyright © 1999 John Wiley & Sons, Ltd.