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FGF7 protein expression in human breast carcinomas
Author(s) -
Jacquemier Jocelyne,
Sun Zhenzhu,
Penaultllorca Frédérique,
Geneix Jeanine,
Devilard Elizabeth,
Adélaïde José,
Birnbaum Daniel
Publication year - 1998
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(1998110)186:3<269::aid-path187>3.0.co;2-g
Subject(s) - human breast , protein expression , expression (computer science) , cancer research , biology , pathology , medicine , oncology , breast cancer , genetics , cancer , gene , computer science , programming language
FGFs, especially FGF7, are thought to play an important role in the stroma–epithelium interactions that take place in several tissues, including the prostate and mammary glands. Using an immunohistochemistry approach, FGF7 protein expression was measured in a series of 80 human breast carcinomas. FGF7 was found to be expressed in two‐thirds of cases studied, either in the stroma or in the tumour cells. Although it did not reach significance level, a tendency was noted for FGF7 expression to be associated with the most differentiated and least aggressive tumours. Copyright © 1998 John Wiley & Sons, Ltd.