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The erbB/HER type 1 tyrosine kinase receptor family
Author(s) -
Walker Rosemary A.
Publication year - 1998
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199807)185:3<234::aid-path128>3.0.co;2-8
Subject(s) - erbb , tyrosine kinase , ror1 , receptor tyrosine kinase , tropomyosin receptor kinase c , cancer research , receptor protein tyrosine kinases , microbiology and biotechnology , proto oncogene tyrosine protein kinase src , biology , receptor , platelet derived growth factor receptor , signal transduction , genetics , growth factor
The erb type 1 tyrosine kinase receptors are important for mediating proliferation and differentiation, and aberrant activation may contribute to tumour development and progression. They comprise epidermal growth factor receptor (EGFR), c‐ erb B‐2, c‐ erb B‐3, and c‐ erb B‐4. There are overlaps and differences in the cellular distribution of the four receptors, which is of significance since they can form heterodimers that give differing responses to different ligands. The different distributions could be of particular importance in cancer if therapeutic modalities are identified to inhibit or stimulate the different ligands. © 1998 John Wiley & Sons, Ltd.