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Tales from the human crypt—intestinal stem cell repertoire and the origins of human cancer
Author(s) -
Playford Raymond J.
Publication year - 1998
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199806)185:2<119::aid-path83>3.0.co;2-3
Subject(s) - crypt , biology , cancer , stem cell , repertoire , colorectal cancer , pathology , cancer research , immunology , medicine , genetics , endocrinology , physics , acoustics
A generally accepted model for the origin of human cancer is that tumours arising from the gut‐lining epithelium—the adenomas and carcinomas—are of clonal origin, i.e. they are derived from a single ‘abnormal’ cell. Recent work has shed considerable light on these matters and suggests that this model may be erroneous and that at least some adenomas are of multiclonal origin. These findings have basic implications for more generalized models of tumourigenesis and for researchers examining the potential clinical value of gene therapy. © 1998 John Wiley & Sons, Ltd.