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Expression of oestrogen receptor and oestrogen‐inducible genes ps2 and erd5 in large bowel mucosa and cancer
Author(s) -
Singh Sukhdev,
Poulsom Richard,
Hanby Andrew M.,
Rogers Len A.,
Wright Nicholas A.,
Sheppard Michael C.,
Langman Michael J. S.
Publication year - 1998
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199802)184:2<153::aid-path993>3.0.co;2-w
Subject(s) - receptor , medicine , in situ hybridization , biology , endocrinology , intestinal mucosa , colorectal cancer , cancer , rectum , estrogen related receptor alpha , progesterone receptor , epithelium , gene expression , estrogen receptor , cancer research , pathology , breast cancer , gene , biochemistry
Since there is a preponderance of large bowel cancer in males, both in humans and in experimental models, and hormone replacement therapy is protective, a role for sex steroid hormones in the pathogenesis of this neoplasm seems likely. Evidence of functional oestrogen receptor has been looked for in large bowel mucosa and cancer. Expression of oestrogen receptor, and of the oestrogen‐inducible receptor‐associated genes pS2 and ERD5, was sought. Oestrogen receptor mRNA was detected in cancers and paired normal mucosae in equal amounts. In situ hybridization identified stromal cells above the muscularis mucosae that were positive for oestrogen receptor mRNA. pS2 mRNA was also detected, with a signal intensity significantly higher in normal mucosa compared with cancers, whereas the reverse was seen with ERD5 mRNA levels. pS2 and ERD5 were expressed in epithelium, with the former in a greater amount in distal colon and rectum than proximal colon. Although oestrogen‐inducible and receptor‐associated genes are expressed in large bowel mucosa, their expression does not correlate with oestrogen receptor. © 1998 John Wiley & Sons, Ltd.