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Glomerular pathology: recent advances
Author(s) -
Gibson I. W.,
More I. A. R.
Publication year - 1998
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199802)184:2<123::aid-path16>3.0.co;2-x
Subject(s) - glomerulopathy , pathology , focal segmental glomerulosclerosis , glomerular basement membrane , glomerulonephritis , glomerulosclerosis , kidney glomerulus , renal pathology , fibronectin , disease , medicine , immunology , biology , kidney , proteinuria , extracellular matrix , microbiology and biotechnology
The last decade has seen significant advances in the fields of cellular and molecular biology and pathology. These have contributed to our understanding of the mechanisms of glomerular disease and indicate possible novel approaches to therapy. This review discusses recent insights into the pathogenesis of glomerular disease, with consideration of the roles of intrinsic glomerular cells, infiltrating inflammatory cells, circulating permeability factors, and antibodies, and recent advances in the molecular pathology of the glomerular basement membrane. Changes in the perception of some well‐established glomerular entities such as focal segmental glomerulosclerosis are considered. In addition, a number of newly‐recognized specific glomerulopathies including collapsing glomerulopathy, fibrillary and immunotactoid glomerulopathy, fibronectin glomerulopathy, and collagenofibrotic glomerulopathy are briefly reviewed. © 1998 John Wiley & Sons, Ltd.