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Kaposi's sarcoma‐associated herpesvirus (KSHV)/human herpesvirus 8 (HHV8)—a new human tumour virus
Author(s) -
Brooks Louise A.,
Wilson Andrew J.,
Crook Tim
Publication year - 1997
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199707)182:3<262::aid-path836>3.0.co;2-q
Subject(s) - virology , virus , biology , genome , gammaherpesvirinae , antibody , gene , herpesviridae , dna virus , viral disease , immunology , genetics
Recently, a novel DNA virus has been molecularly cloned from Kaposi's sarcoma (KS) tissue, a tumour common in acquired immune deficiency syndrome (AIDS). Analysis of the viral genome confirms that it is a relative of human herpesviruses and the virus has been designated HHV‐8. Epidemiological evidence suggests a strong aetiological link between the presence of HHV‐8 DNA and/or antibodies against the virus, and KS. Additional sequence analysis suggests that the HHV‐8 genome contains sequences which encode a D type cyclin and a number of other genes potentially implicated in growth deregulation which may be relevant to its proposed role as a transforming virus. © 1997 John Wiley & Sons, Ltd.