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EXPRESSION OF THE TYPE 1 TYROSINE KINASE GROWTH FACTOR RECEPTORS EGF RECEPTOR, c‐erbB2 AND c‐erbB3 IN BLADDER CANCER
Author(s) -
RAJKUMAR THANGARAJAN,
STAMP GORDON W. H.,
PANDHA HARDEV S.,
WAXMAN JONATHAN,
GULLICK WILLIAM J.
Publication year - 1996
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199608)179:4<381::aid-path603>3.0.co;2-x
Subject(s) - erbb3 , epidermal growth factor , receptor , receptor tyrosine kinase , immunohistochemistry , tyrosine kinase , epidermal growth factor receptor , growth factor receptor , biology , bladder cancer , cancer research , medicine , cancer , endocrinology , microbiology and biotechnology
Expression of the c‐erbB3 protein was determined in transitional cell carcinoma of the bladder by immunohistochemistry. Strong membrane staining was observed in 10 per cent of cases (7/70) and cytoplasmic and membrane overexpression in 20 per cent (14/70). Overexpression of the epidermal growth factor (EGF) receptor (36 per cent, 25/70) and c‐erbB2 proteins (9 per cent 6/70) was determined in the same series of cases. c‐erbB3 overexpression was positively correlated with EGF receptor expression ( P <0·025) but appeared to be inversely associated with c‐erbB2 overexpression.