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PHENOTYPIC MODULATION OF HODGKIN AND REED–STERNBERG CELLS BY EPSTEIN–BARR VIRUS
Author(s) -
HERBST HERMANN,
RAFF THORSTEN,
STEIN HARALD
Publication year - 1996
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199605)179:1<54::aid-path537>3.0.co;2-2
Subject(s) - reed–sternberg cell , phenotype , virus , virology , epstein–barr virus , biology , immunology , lymphoma , genetics , hodgkin lymphoma , gene
Expression of the Epstein–Barr virus (EBV) gene product LMP1 is found in tumour cells in varying proportions of Hodgkin's disease (HD) cases. It is not clear which cellular genes are influenced by EBV in HD. A total of 387 HD cases were tested for differences among LMP1‐positive and ‐negative cases with respect to age, sex, histotype and immunophenotypic parameters (CD2, CD3, CD4, CD15, CD19, CD20, CD21, CD22, CD23, CD25, CD30, CD43, CD45RA, CD45R0, CD70, HLA‐DR, T‐cell receptor β‐chain, and p53 expression). Comparison of patient age and sex as well as distribution of histotype and tumour cell immunophenotype with published data suggests that the cases in this study are representative of the spectrum of HD in developed countries. LMP1 expression was found in 131/387 HD cases (36·4 per cent) with non‐homogeneous distribution among HD histotypes, the mixed cellularity type (HDmc) being most frequently EBV‐associated (71/129 cases, 55 percent). No relationship was found to age and sex. Significant phenotypic differences were restricted to the HDmc histotype, where the tumour cells expressed the activation marker CD30 in a larger proportion, and CD20 in a smaller proportion, when harbouring EBV. These results suggest that EBV may influence the tumour cell phenotype in HD.