Premium
THREE‐DIMENSIONAL RECONSTRUCTION OF BENIGN LYMPHOID AGGREGATES IN BONE MARROW TREPHINES
Author(s) -
SALISBURY JONATHAN R.,
DEVERELL MARK H.,
COOKSON M. JOHN
Publication year - 1996
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199604)178:4<447::aid-path489>3.0.co;2-n
Subject(s) - bone marrow , lymphoma , trephine , pathology , lymphatic system , hodgkin lymphoma , medicine
Distinguishing between deposits of low‐grade non‐Hodgkin's lymphoma and benign lymphoid aggregates in bone marrow trephine sections is a recognized problem in haematopathology. To test the hypothesis that benign lymphoid aggregates do not make contact with a trabecular surface, three‐dimensional models were constructed of five serially sectioned bone marrow trephines, containing a total of 19 lymphoid aggregates known to be benign. The computer‐generated images showed that benign lymphoid aggregates were located in the central marrow space and did not become paratrabecular. This suggests that a paratrabecular location may help in some cases to distinguish deposits of low‐grade non‐Hodgkin's lymphoma from benign lymphoid aggregates.