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IMMUNOHISTOCHEMICAL STUDY OF OVEREXPRESSION OF FIBROBLAST GROWTH FACTOR‐1 (FGF‐1), FGF‐2, AND FGF RECEPTOR‐1 IN HUMAN MALIGNANT SALIVARY GLAND TUMOURS
Author(s) -
MYOKEN YOSHIKO,
MYOKEN YOSHINARI,
OKAMOTO TETSUJI,
SATO J. DENRY,
KAN MIKIO,
McKEEHAN WALLACE L.,
NAKAHARA MITSURU,
TAKADA KAZUAKI
Publication year - 1996
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199604)178:4<429::aid-path495>3.0.co;2-1
Subject(s) - fibroblast growth factor , salivary gland , fibroblast growth factor receptor , immunohistochemistry , adenoid cystic carcinoma , myoepithelial cell , biology , salivary gland cancer , mucoepidermoid carcinoma , endocrinology , pathology , immunostaining , medicine , cancer research , receptor , carcinoma
Fibroblast growth factor‐1 (FGF‐1) and FGF‐2 are broad spectrum mitogens. The expression of FGF‐1, FGF‐2, and their receptor, FGF receptor‐1 (FGFR‐1), was examined in malignant salivary gland tumours and normal salivary glands, using immunohistochemical methods. In seven cases of adenoid cystic carcinoma (ACC), both duct‐like cells and modified myoepithelial cells were apparently immunopositive for FGF‐1, FGF‐2, and FGFR‐1. In five cases of mucoepidermoid carcinoma (MC), all three types of tumour cells including epidermoid cells, mucous cells, and intermediate cells expressed immunoreactive FGF‐1, FGF‐2, and FGFR‐1. In these malignant salivary gland tumours, increased expression of FGFR‐1 correlated with the intensity of both FGF‐1 and FGF‐2 immunoreactivity. In contrast to malignant salivary gland tumours, eight cases of normal salivary gland showed negative immunostaining for FGF‐1, FGF‐2, and FGFR‐1 while four cases were weakly immunoreactive for FGF and its receptor. These results demonstrate that malignant salivary gland tumours overexpress FGF‐1, FGF‐2, and FGFR‐1 compared with normal salivary glands and suggest that these growth factors may play an important role in facilitating neoplastic progression in human salivary glands.