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14Q+ CHROMOSOME MARKER IN A T‐CELL‐RICH B‐CELL LYMPHOMA
Author(s) -
LA STARZA ROBERTA,
AVENTIN ANA,
FALZETTI DANIELA,
STUL MICHEL,
MARTELLI MASSIMO F.,
FALINI BRUNANGELO,
MECUCCI CRISTINA
Publication year - 1996
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199602)178:2<227::aid-path437>3.0.co;2-9
Subject(s) - lymphoma , chromosome , cell , biology , b cell , marker chromosome , genetics , immunology , karyotype , antibody , gene
Cytogenetic, in situ hybridization, and molecular studies were performed in a case of T‐cell‐rich B‐cell lymphoma. Demonstration of Ig gene rearrangements for both heavy and light chains confirmed the B‐lineage restriction of the neoplastic cell population. Moreover, as expected in B‐cell malignancies, all abnormal karyotypes showed a 14q+, as defined by chromosome painting with a library for chromosome 11, and Southern blotting for c‐ myc and bcl ‐2 rearrangements, remains unknown