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OVEREXPRESSION OF DIFFERENT MEMBERS OF THE TYPE 1 GROWTH FACTOR RECEPTOR FAMILY AND THEIR ASSOCIATION WITH CELL PROLIFERATION IN PERIAMPULLARY CARCINOMA
Author(s) -
VAIDYA PRADEEP,
KAWARADA YOSHIFUMI,
HIGASHIGUCHI TAKASHI,
YOSHIDA TOSHIMICHI,
SAKAKURA TERUYO,
YATANI RYUICHI
Publication year - 1996
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199602)178:2<140::aid-path450>3.0.co;2-u
Subject(s) - cancer research , carcinoma , association (psychology) , receptor , cell growth , biology , oncology , medicine , genetics , psychology , psychotherapist
The expression of epidermal growth factor receptor (EGFR), c‐ erb B‐2, and c‐ erb B‐3 was examined immunohistochemically in 57 cases of periampullary carcinoma. The percentage of Ki‐67‐positive cells was also examined in the same tissue, to determine the relationship between the expression of the members of the type 1 growth factor receptor family and cell proliferation. In carcinoma of the head of pancreas, the percentage of cases with overexpression of c‐ erb B‐3 was significantly higher than with overexpression of c‐ erb B‐2 and EGFR. In contrast, in lower bile duct carcinoma and carcinoma of the ampulla of Vater, the percentages of cases with overexpression of c‐ erb B‐2 was greater than with overexpression of other growth factor receptors. A higher percentage of cases with overexpression of c‐ erb B‐3 in pancreatic head carcinoma and overexpression of c‐ erb B‐2 in carcinoma of the ampulla of Vater was found in Ki‐67 antigen‐positive cases. Moreover, the overexpression of c‐ erb ‐3 in pancreatic head carcinoma, c‐ erb ‐2 in ampulla of Vater carcinoma, and Ki‐67 in both carcinomas was found to be associated with poor patient outcome. These results demonstrate that different members of the type 1 growth factor receptor family are overexpressed in different carcinomas of the periampullary region.