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Chromium(III) interactions with nucleosides and nucleotides: a mass spectrometric study
Author(s) -
Madhusudanan K. P.,
Katti S. B.,
Vijayalakshmi R.,
Nair B. U.
Publication year - 1999
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/(sici)1096-9888(199908)34:8<880::aid-jms844>3.0.co;2-e
Subject(s) - chemistry , chromium , nucleotide , environmental chemistry , medicinal chemistry , organic chemistry , biochemistry , gene
Interactions of [Cr(salprn)(H 2 O) 2 ]ClO 4 with nucleosides and dinucleotides were studied using electrospray ionization mass spectrometry. The nucleosides 2′‐deoxycytidine, thymidine, 2′‐deoxyadenosine, 2′‐deoxyguanosine, cytidine, adenosine and guanosine form 1 : 1 and 2 : 1 adducts with [Cr(salprn)] + , whereas the dinucleotides CpG, GpC, ApT, TpA and TpC form only the 1 : 1 adducts. Collisional activation (CA) spectra of these adducts reveal that Cr + attaches to the bases in nucleosides and to both the phosphate and base, especially cytosine and guanine moieties, in the nucleotides. The sugar residues appear to offer no binding sites as elimination of sugar residues is fairly abundant in the CA spectra of the adducts of many of the nucleosides. Copyright © 1999 John Wiley & Sons, Ltd.