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Comparative mass spectrometric analyses of Photofrin oligomers by fast atom bombardment mass spectrometry, UV and IR matrix‐assisted laser desorption/ionization mass spectrometry, electrospray ionization mass spectrometry and laser desorption/jet‐cooling photoionization mass spectrometry
Author(s) -
Siegel Marshall M.,
Tabei Keiko,
Tsao Rushung,
Pastel Michael J.,
Pandey Ravindra K.,
Berkenkamp Stefan,
Hillenkamp Franz,
de Vries Mattanjah S.
Publication year - 1999
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/(sici)1096-9888(199906)34:6<661::aid-jms818>3.0.co;2-i
Subject(s) - chemistry , mass spectrometry , fast atom bombardment , soft laser desorption , porphyrin , mass spectrum , electrospray ionization , photoionization , analytical chemistry (journal) , matrix assisted laser desorption electrospray ionization , oligomer , ionization , desorption , matrix assisted laser desorption/ionization , electron ionization , photochemistry , ion , chromatography , organic chemistry , adsorption
Photofrin ® (porfimer sodium) is a porphyrin derivative used in the treatment of a variety of cancers by photodynamic therapy. This oligomer complex and a variety of porphyrin monomers, dimers and trimers were analyzed with five different mass spectral ionization techniques: fast atom bombardment, UV and IR matrix‐assisted laser desorption/ionization, electrospray ionization, and laser desorption/jet‐cooling photoionization. All five approaches resulted in very similar oligomer distributions with an average oligomer length of 2.7 ± 0.1 porphyrin units. In addition to the Photofrin analysis, this study provides a side‐by‐side comparison of the spectra for the five different mass spectrometric techniques. Copyright © 1999 John Wiley & Sons, Ltd.