Premium
Fragmentation of Bosentan ® (Ro 47‐0203) in ionspray mass spectrometry after collision‐induced dissociation at low energy: a case of radical fragmentation of an even‐electron ion
Author(s) -
Hopfgartner G.,
Vetter W.,
Meister W.,
Ramuz H.
Publication year - 1996
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/(sici)1096-9888(199601)31:1<69::aid-jms264>3.0.co;2-q
Subject(s) - chemistry , bosentan , fragmentation (computing) , tandem mass spectrometry , mass spectrometry , dissociation (chemistry) , ion , collision induced dissociation , endothelin receptor , chromatography , organic chemistry , receptor , biochemistry , computer science , operating system
For metabolic studies the fragmentation of a novel endothelin receptor antagonist, Bosentan, was investigated using ionspray tandem mass spectrometry. Bosentan belongs to the sulphonamide class and a complicated and unexpected fragmentation at low energy, involving a radical fragmentation of an even‐electron ion at the sulphonamide bond, is reported.