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PACAP and glutamate are co‐stored in the retinohypothalamic tract
Author(s) -
Hannibal Jens,
Moller Morten,
Ottersen Ole Petter,
Fahrenkrug Jan
Publication year - 2000
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/(sici)1096-9861(20000306)418:2<147::aid-cne2>3.0.co;2-#
Subject(s) - suprachiasmatic nucleus , glutamate receptor , circadian rhythm , neuroscience , biology , medicine , endocrinology , microbiology and biotechnology , chemistry , receptor
The retinohypothalamic tract (RHT) relays photic information from the eyes to the suprachiasmatic nucleus (SCN). Activation of this pathway plays a role in adjusting circadian timing to the light/dark environment. Two transmitters, glutamate and pituitary adenylate cyclase activating polypeptide (PACAP) having phase shifting capacity during the night and day, respectively, are located in the RHT. Using double staining immunohistochemistry at the light and electron microscopic level, we showed that PACAP was co‐stored with glutamate in a subset of retinal ganglion cells and in nerve terminals in the retino‐recipient area of the SCN. These findings provide an anatomical basis for the recent demonstration of the interaction between these two transmitters on the SCN phase response at night. J. Comp. Neurol. 418:147–155, 2000. © 2000 Wiley‐Liss, Inc.