Premium
Chronic electrical stimulation by a cochlear implant promotes survival of spiral ganglion neurons after neonatal deafness
Author(s) -
Leake Patricia A.,
Hradek Gary T.,
Snyder Russell L.
Publication year - 1999
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/(sici)1096-9861(19991004)412:4<543::aid-cne1>3.0.co;2-3
Subject(s) - spiral ganglion , stimulation , cochlear implant , round window , ganglion , audiology , medicine , implant , cochlea , biology , anatomy , surgery
This investigation examined the consequences of neonatal deafness and chronic intracochlear electrical stimulation delivered by a cochlear implant during maturation. Kittens were bilaterally deafened by an ototoxic drug administered daily for 2 weeks immediately after birth. Unilateral electrical stimulation was initiated at 7–10 weeks of age and continued over periods of 22–47 weeks (4 hours/day; 5 days/week). Bipolar intracochlear electrodes delivered one of several different electrical signals designed to be temporally challenging to the central auditory system. Morphometric evaluation of spiral ganglion (SG) cell somata within Rosenthal's canal demonstrated a mean of ≈50% of normal cell density maintained in the chronically stimulated ears, compared with ≈30% on the control deafened side. This 20% difference in density was highly significant and was greater than differences reported in earlier studies using 30 pps stimulation delivered by either intracochlear bipolar or round window monopolar electrodes. However, the duration of stimulation was also longer in the present study, so it is unclear to what extent the nature of the temporally challenging stimulation vs. its duration contributed to the marked increase in survival. Measurements of the SG cell somata revealed a pronounced decrease in cell diameter in neonatally deafened cats studied about 1 year after deafening, and an additional decrease after long‐term deafness (2.5–6.5 years). Furthermore, in the cochlear regions with the greatest stimulation‐induced differences in SG cell density, direct measurements of cross‐sectional soma area of the largest cells revealed that cells were significantly larger in the stimulated ears. Thus, in addition to the marked increase in the number of surviving SG cells, larger soma area contributed modestly to the pronounced increase in neural density following chronic electrical stimulation. J. Comp. Neurol. 412:543–562, 1999. © 1999 Wiley‐Liss, Inc.