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Fiber system linking the mid‐dorsolateral frontal cortex with the retrosplenial/presubicular region in the rhesus monkey
Author(s) -
Morris Renée,
Pandya Deepak N.,
Petrides Michael
Publication year - 1999
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/(sici)1096-9861(19990503)407:2<183::aid-cne3>3.0.co;2-n
Subject(s) - retrosplenial cortex , neuroscience , dorsolateral , cingulum (brain) , hippocampal formation , anatomy , frontal cortex , cortex (anatomy) , hippocampus , psychology , biology , medicine , white matter , prefrontal cortex , fractional anisotropy , cognition , magnetic resonance imaging , radiology
The present study investigated the origin, course, and terminations of the association fiber system linking the frontal cortex with the hippocampal system by means of the cingulum bundle. Injections of tritiated amino acids were placed within individual cytoarchitectonic areas of the frontal cortex in the rhesus monkey. It was demonstrated that the mid‐dorsolateral frontal cortex (areas 46, 9/46, and 9) and its medial extension (medial areas 9 and 9/32) is the origin of a specific fiber pathway, running posteriorly as part of the cingulum bundle, and terminating mainly in the retrosplenial area 30 and the posterior presubiculum. This fiber bundle therefore provides the anatomical substrate of a functional interaction between the mid‐dorsolateral frontal cortex and the hippocampal memory system for the monitoring of information within working memory. J. Comp. Neurol. 407:183–192, 1999. © 1999 Wiley‐Liss, Inc.