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PMP ‐22 expression in the central nervous system of the embryonic mouse defines potential transverse segments and longitudinal columns
Author(s) -
Parmantier Eric,
Braun Christine,
Thomas JeanLéon,
Peyron Fabienne,
Martinez Salvador,
Zalc Bernard
Publication year - 1997
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/(sici)1096-9861(19970210)378:2<159::aid-cne1>3.0.co;2-2
Subject(s) - forebrain , biology , spinal cord , basal plate (neural tube) , midbrain , anatomy , central nervous system , peripheral nervous system , neuroscience , fetus , placenta , pregnancy , genetics
PMP‐22, a major constituent of peripheral nervous system (PNS) myelin, is also present in the central nervous system (CNS), in motoneurons of the cranial nerve motor nuclei and spinal cord (Parmantier et al. [1995] Eur. J. Neurosci. 7:1080–1088). The expression of PMP‐22 in the CNS during embryonic and early postnatal development was investigated and showed a biphasic spatio‐temporal pattern. The expression of PMP‐22 started at embryonic day (E)11.5, in restricted longitudinal and transverse domains, in the ventricular zone of the spinal cord, rhombencephalon, mesencephalon and prosencephalon. In the mid‐ and forebrain, the PMP‐22 signal was detectable in a longitudinal domain that followed ventrally the basal/alar boundary but could no longer be detected dorsally at some distance from the roof plate. Along the caudo‐rostral axis, the territory in which PMP ‐22 was detected spanned the mesencephalon and the prosencephalon, extending caudally from the limit between the isthmus and the mesencephalon, and rostrally to the boundary between prosomeres 4 and 5 (p4/p5). In agreement with the prosomeric model of forebrain organization proposed by Puelles and Rubenstein ([1993] TINS 16:472–479), differences in the level of PMP ‐22 expression in p2, p3, and p4 clearly defined the p2/p3 and p3/p4 neuromeric boundaries. By E17.5, PMP ‐22 was no longer detected in the ventricular zone, but at E18.5 it began to be expressed in motoneurons of cranial nerve motor nuclei and, after birth, following a rostro‐caudal gradient, in the ventral spinal cord. J. Comp. Neurol. 378:159–172, 1997. © 1997 Wiley‐Liss, Inc.