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The neostriatal mosaic: Basis for the changing distribution of neurokinin‐1 receptor immunoreactivity during development
Author(s) -
Ardelt Agnieszka A.,
Karpitskiy Vladimir V.,
Krause James E.,
Roth Kevin A.
Publication year - 1996
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/(sici)1096-9861(19961216)376:3<463::aid-cne8>3.0.co;2-0
Subject(s) - biology , compartment (ship) , tachykinin receptor 1 , substance p , receptor , neuropeptide , microbiology and biotechnology , cholinergic , neuroscience , biochemistry , oceanography , geology
The pattern of neurokinin‐1 receptor‐like immunoreactivity (NK‐1Rir) was mapped in perinatal and adult mouse striatum by using a new polyclonal antiserum. NK‐1Rir was detected in the differentiating regions of the ganglionic eminences on embryonic day 12.5 (E12.5). NK‐1Rir structures were enriched in the striatal patch compartment between E16.5 and approximately postnatal day 3 (P3); distributed more uniformly, within portions of both the patch and matrix compartments on P7; and enriched in the matrix compartment in the adult. Analysis of the phenotype of NK‐1Rir cells on P2, P7, and in the adult suggested that cholinergic cells accounted for the majority of NK‐1Rir cells early postnatally, with increasing contributions from somatostatinergic cells later postnatally. In the adult, approximately half of NK‐1Rir cells were cholinergic and half were somatostatinergic. The transient enrichment of NK‐1R‐bearing cells and processes in the patch compartment which contains cells that express substance P (SP), a putative ligand for the NK‐1R, may be a consequence of compartment formation or may be functionally important for compartment development. © 1996 Wiley‐Liss, Inc.