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Quantitative MRI of the temporal lobe, amygdala, and hippocampus in normal human development: Ages 4–18 years
Author(s) -
Giedd Jay N.,
Vaituzis A. Catherine,
Hamburger Susan D.,
Lange Nicholas,
Rajapakse Jagath C.,
Kaysen Debra,
Vauss Yolanda C.,
Rapoport Judith L.
Publication year - 1996
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/(sici)1096-9861(19960304)366:2<223::aid-cne3>3.0.co;2-7
Subject(s) - amygdala , temporal lobe , hippocampus , hippocampal formation , laterality , neuroimaging , psychology , neuroscience , brain size , superior temporal gyrus , magnetic resonance imaging , audiology , medicine , functional magnetic resonance imaging , radiology , epilepsy
The volume of the temporal lobe, superior temporal gyrus, amygdala, and hippocampus was quantified from magnetic images of the brains of 99 healthy children and adolescents aged 4–18 years. Variability in volume was high for all structures examined. When adjusted for a 9% larger total cerebral volume in males, there were no significant volume differences between sexes. However, sex‐specific maturational changes were noted in the volumes of medial temporal structures, with the left amygdala increasing significantly only in males and with the right hippocampus increasing significantly only in females. Right‐greater‐than‐left laterality effects were found for temporal lobe, superior temporal gyrus, amygdala, and hippocampal volumes. These results are consistent with previous preclinical and human studies that have indicated hormonal responsivity of these structures and extend quantitative morphologic findings from the adult literature. In addition to highlighting the need for large samples and sex‐matched controls in pediatric neuroimaging studies, the information from this understudied age group may be of use in evaluating developmental hypotheses of neuropsychiatric disorders. © 1996 Wiley‐Liss, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America.