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Immunocytochemical localization of the α 6 subunit of the γ‐aminobutyric acid A receptor in the rat nervous system
Author(s) -
Gutiérrez Antonia,
Khan Zafar U.,
De Blas Angel L.
Publication year - 1996
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/(sici)1096-9861(19960212)365:3<504::aid-cne12>3.0.co;2-q
Subject(s) - biology , protein subunit , neuroscience , nervous system , receptor , central nervous system , microbiology and biotechnology , genetics , gene
Abstract The localization in the rat central nervous system and retina of the α 6 subunit peptide of the γ‐aminobutyric acid (GABA A ) receptor has been studied by light microscopy immunocytochemistry with a specific anti‐α 6 antibody. The α 6 subunit was present in the granule cells of the cerebellum, the granule cells of the dorsal cochlear nucleus, axons of the olfactory nerve including the glomerular endings, layer II of the dorsal horn of the spinal cord, and in the retinal synaptic layers, particularly the inner plexiform layer. Thus, contrary to the general belief, the α 6 subunit is not exclusively localized in the granule cells of the cerebellum. It is also expressed in some sensory neurons and other neurons involved in the initial processing of sensory information. © 1996 Wiley‐Liss, Inc.