Premium
GaAs (904‐nm) laser radiation does not affect muscle regeneration in mouse skeletal muscle
Author(s) -
Oliveira Nuno M.L.,
Parizzotto Nivaldo A.,
Salvini Tania F.
Publication year - 1999
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/(sici)1096-9101(1999)25:1<13::aid-lsm3>3.0.co;2-7
Subject(s) - skeletal muscle , irradiation , laser , regeneration (biology) , tibialis anterior muscle , muscle tissue , medicine , chemistry , anatomy , materials science , biology , optics , physics , nuclear physics , microbiology and biotechnology
Background and Objective We evaluated the effect of GaAs (904‐nm) laser, applied directly to the skin of injured muscle, in muscle regeneration. Study Design/Material and Methods Muscle injury was induced in the Tibialis anterior (TA) muscle by ACL myotoxin (5 mg/kg). Two groups were irradiated with doses of 3 (n = 8) and 10 J/cm 2 (n = 8). GaAs laser (power 1.5 mW, intensity 7.5 mW/cm 2 , spot 0.2 cm 2 ) was applied daily for five days. Contralateral TA received a sham procedure. Results Similar morphological aspects were found in both laser irradiated and sham muscles. No differences were found in the muscle weight, but animals irradiated with 10 J/cm 2 showed a significant gain of body weight ( P = 0.002). Conclusions Doses of 3 and 10 J/cm 2 of GaAs laser were not efficient to promote significant morphological changes in the regenerated skeletal muscle, but the dose of 10 J/cm 2 promoted significant gain of body weight. Lasers Surg. Med. 25:13–21, 1999. © 1999 Wiley‐Liss, Inc.