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Selective occlusion of choroidal neovascularization by photodynamic therapy with a water‐soluble photosensitizer, ATX‐S10
Author(s) -
Obana Akira,
Gohto Yuko,
Kaneda Kenji,
Nakajima Susumu,
Takemura Takeshi,
Miki Tokuhiko
Publication year - 1999
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/(sici)1096-9101(1999)24:3<209::aid-lsm6>3.0.co;2-l
Subject(s) - photosensitizer , photodynamic therapy , choroidal neovascularization , ophthalmology , neovascularization , medicine , occlusion , chemistry , surgery , photochemistry , cancer research , angiogenesis , macular degeneration , organic chemistry
Background and Objective To determine the optimal treatment parameters for selective occlusion of choroidal neovascularization (CNV) by photodynamic therapy (PDT) by using the photosensitizer ATX‐S10 and a diode laser (wavelength = 670 nm). Materials and Methods Experimental CNV was induced in rat fundi by argon laser photocoagulation. The distribution of ATX‐S10 in the chorioretina was analyzed by fluorescence microscopy, and the optimal treatment parameters for selective occlusion of CNV were investigated by changing the dosage and timing of laser irradiation. CNV closure and resulting damage of the surrounding tissue were documented by fluorescein angiography and light and electron microscopies. Results Fluorescence of ATX‐S10 was observed to be localized in the vascular lumen of the retina and choroid within 5 min after dye injection and increased in intensity in CNV up to 2–6 h and decreased rapidly in normal tissue. Laser irradiation with radiant exposures of 7.4 J/cm 2 applied immediately after dye injection or with 22.0 J/cm 2 at 2–4 h later effectively occluded the induced CNV without causing significant damage to normal retinal capillaries and large choroidal vessels. Conclusions PDT using ATX‐S10 can selectively occlude CNV. ATX‐S10 is a potentially useful photosensitizer for the treatment of CNV. Lasers Surg. Med. 24:209–222, 1999. © 1999 Wiley‐Liss, Inc.