Premium
In vitro and in vivo comparison of argon‐pumped and diode lasers for photodynamic therapy using second‐generation photosensitizers
Author(s) -
HammerWilson Marie J.,
Sun ChungHo,
Ghahramanlou Marjan,
Berns Michael W.
Publication year - 1998
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/(sici)1096-9101(1998)23:5<274::aid-lsm7>3.0.co;2-o
Subject(s) - laser , photodynamic therapy , argon , materials science , diode , optoelectronics , dye laser , chinese hamster ovary cell , optics , chemistry , physics , biochemistry , receptor , organic chemistry
Background and Objective Three prototype microchannel‐cooled stacked diode array lasers were compared with the currently used conventional argon ion laser‐pumped tunable dye lasers for suitability as light sources in photodynamic therapy (PDT) treatment. Study Design/Materials and Methods The PDT response of Chinese hamster ovary (CHO‐K1) cells in culture and SMT‐F tumor bearing mice treated with chloro‐aluminum sulfonated phthalocyanin (CASPc), benzoporphyrin derivative mono‐acid (BPD‐MA), and lutetium texaphyrin (Lutex) was determined using each laser light source. Survival of the CHO cells was measured using a cloning assay. Tumor regression/eradication was used to assess response in the mice. Results Both sources of laser light produced comparable PDT responses in the two systems tested. Conclusion It would be possible to replace the currently used argon ion laser‐pumped dye laser systems with the diode lasers tested. Lasers Surg. Med. 23:274–280, 1998. © 1998 Wiley‐Liss, Inc.