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Nd:YAG interstitial laser thermotherapy in the treatment of breast cancer
Author(s) -
Akimov Alexander B.,
Seregin Victor E.,
Rusanov Konstantin V.,
Tyurina Eugenia G.,
Glushko Tatyana A.,
Nevzorov Vyacheslav P.,
Nevzorova Olga F.,
Akimova Elena V.
Publication year - 1998
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/(sici)1096-9101(1998)22:5<257::aid-lsm1>3.0.co;2-o
Subject(s) - medicine , breast cancer , laser , cancer , optics , physics
Background and Objective “Minimal treatment strategy” is desirable in certain breast cancer patients. The main objective of the present study is to examine the use of interstitial laser thermotherapy (laserthermia) for this purpose. Study Design/Materials and Methods: Thirty‐five patients with primary breast cancer were treated with laserthermia using the Nd:YAG (1,064 nm) pulse‐wave laser. In 28 patients, laserthermia was performed before radical resection, and in seven patients it was the only invasive treatment. Results One gaseous rupture of tumor occurred at 3 Watts. The diameter of single focus of laser‐induced damage after 1–2 Watts was less than 1 cm, and after 2.5–6 Watts it reached 1.5–2.5 cm. Of seven patients treated without surgery, local tumor control was achieved in five, and in three stage I–III patients disease‐free survival followed for 19–60 months. After laserthermia plus surgery, 3‐year disease‐free survival was 27% in premenopausal and 92% in menopausal patients. Conclusions It seems that laser destruction of relatively small primary breast cancer is possible. Provisionally, laserthermia should not be used in premenopausal patients. Lasers Surg. Med. 22:257–267, 1998. © 1998 Wiley‐Liss, Inc.