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Effect of low‐power laser irradiation on the mechanical properties of bone fracture healing in rats
Author(s) -
Luger Elchanan J.,
Rochkind Semion,
Wollman Yoram,
Kogan Galina,
Dekel Shmuel
Publication year - 1998
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/(sici)1096-9101(1998)22:2<97::aid-lsm5>3.0.co;2-r
Subject(s) - bone healing , irradiation , fracture (geology) , laser , materials science , dentistry , biomedical engineering , medicine , composite material , surgery , optics , physics , nuclear physics
Background and Objective Low‐power laser irradiation (LPLI) has been found to have a positive effect on bone fracture healing in animal models, based on morphogenic, biochemical, roentgenographic, and electron microscopic measurements. We investigated the effect of LPLI on bone fracture healing in rats using biomechanical methods. Study Design/Materials and Methods: Two groups of male Wistar rats, divided in a randomized block design in a blinded fashion, each consisting of 25 animals, were subjected to anesthesia and tibial bone fracture with internal fixation. The first group was treated with LPLI (HeNe laser 632.8 nm, 35 mW), applied transcutaneously over 30 minutes to the area of the fracture daily for 14 days. The second group served as a control. After 4 weeks, the tibia was removed and tested at tension up to failure (by a Lloyd LR 50K testing apparatus, U.K.) in 16 rats from group I and 15 from group II. The maximal load at failure, the structural stiffness of the tibia (callus stiffness), and the extension maximal load were measured. Results The maximal load at failure and the structural stiffness of the tibia were found to be elevated significantly in the irradiated group ( P = .014 and P = .0023, respectively), whereas the extension maximal load was reduced ( P = .015). In addition, gross non‐union was found in four fractures in the control group, compared to none in the irradiated group. Conclusion These results suggest that LPLI treatment may play a role in enhancing bone healing. Lasers Surg. Med. 22:97–102, 1998. © 1998 Wiley‐Liss, Inc.