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Photodynamic therapy for Barrett's esophagus: Cardiac effects
Author(s) -
Overholt Bergein F.,
Panjehpour Masoud,
Ayres Mike
Publication year - 1997
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/(sici)1096-9101(1997)21:4<317::aid-lsm2>3.0.co;2-t
Subject(s) - medicine , esophagus , photodynamic therapy , atrial fibrillation , adverse effect , cardiology , gastroenterology , organic chemistry , chemistry
Background and Objective Atrial fibrillation has been reported following esophageal photodynamic therapy. This study presents the results of serial cardiac testing following photodynamic therapy for patients with Barrett's esophagus and with dysplasia or early carcinoma. Study Design/Materials and Methods Twelve patients were treated using photodynamic therapy. Serum creatinine phosphokinase and lactic dehydrogenase isoenzyme levels were determined pretreatment and 24, 48, and 72 hours after treatment. Electrocardiograms were obtained before and 48 hours after treatment. A rhythm strip was obtained 1 week posttreatment. Clinical assessment for cardiac arrhythmias occurred daily following therapy. Results Transient atrial fibrillation was noted in one patient during a follow‐up endoscopy. However, no significant or permanent abnormality was noted in cardiac enzymes or electrocardiograms. Conclusion No permanent electrocardiographic changes or significant abnormalities in cardiac enzymes were detected following esophageal photodynamic therapy in patients with or without histories of cardiac disease. Delivery of esophageal PDT is not associated with permanent adverse cardiac effects. Lasers Surg. Med. 21:317–320, 1997. © 1997 Wiley‐Liss, Inc.