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Three‐dimensional optical phantom and its application in photodynamic therapy
Author(s) -
Bays Roland,
Wagnières Georges,
Robert Dimitri,
Theumann JeanFrançois,
Vitkin Alex,
Savary JeanFrançois,
Monnier Philippe,
van den Bergh Hubert
Publication year - 1997
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/(sici)1096-9101(1997)21:3<227::aid-lsm2>3.0.co;2-s
Subject(s) - photodynamic therapy , imaging phantom , biomedical engineering , medical physics , medicine , optics , materials science , nuclear medicine , chemistry , physics , organic chemistry
Background and Objective A technique to manufacture a stable, reproducible three‐dimensional optical phantom is presented. This phantom reproduces the tissue's optical properties as well as the geometry and, to some extent, the mechanical properties of the organ concerned. Easy to make and to handle, this phantom is a useful tool for numerous medical applications involving light interaction with biological tissues. Study Design/Materials and Methods The phantom is based on a transparent two‐component silicone, which is molded into the desired shape and cured at room temperature. Specific optical properties are obtained by adding scatterers (Al 2 O 3 particles or polystyrene microspheres) and absorbers (dyes or pigments). A method to measure the radiant energy fluence rate in the phantom is described. This method is based on a small isotropic optical detector. Results A three‐dimensional phantom of the bronchial tree is presented. This phantom is used for testing new light distributors designed for photodynamic therapy of the bronchi. Conclusion The proposed technique allows one to produce a stable three‐dimensional phantom with accurately predictable optical properties. Lasers Surg. Med. 21:227–234, 1997. © 1997 Wiley‐Liss, Inc.