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Long‐term follow‐up of cervical intraepithelial neoplasia treated with minimal conization by carbon dioxide laser
Author(s) -
Békássy Zoltán
Publication year - 1997
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/(sici)1096-9101(1997)20:4<461::aid-lsm13>3.0.co;2-e
Subject(s) - medicine , carbon dioxide laser , cervical intraepithelial neoplasia , colposcopy , cervical conization , surgery , carcinoma , endocervical curettage , carcinoma in situ , cervical carcinoma , curettage , laser surgery , cervical cancer , laser , cancer , physics , optics
Background and Objective Minimal conization with carbon dioxide laser (CO 2 ) for safe diagnosis and treatment of cervical intraepithelial neoplasia (CIN) 1–3 has been utilized for 15 years. To evaluate the results of 15 years' follow‐up. Study Design/Materials and Methods: Clinical prospective study: 2,903 non‐pregnant women whose cervicovaginal smear revealed CIN 1–3, confirmed by colposcopy, were referred for minimal conization treatment (LMC). This outpatient free‐hand excision is performed under local anesthesia with a 60‐W continuous laser beam focused to a 0.1‐mm spot size, giving a power density of 165,000 W/cm 2 . Adjuvant cervical curettage is done routinely. Results Complications after the procedure were insignificant. Histopathological investigation revealed invasive carcinoma in 1.2% of the minicones. The primary cure rate was 96.1%. In the life table analysis of the patients the cumulative risk of recurrence for all forms of CIN was 0.89% at year 5, 1.36% at year 10, and 3.02% at year 15. There was no sudden onset carcinoma during the follow‐up period. Conclusion Minimal conization is a safe, effective treatment for CIN and early forms of microinvasive carcinoma. Invasive carcinoma can be detected early and should be treated without delay. The cumulative risk of developing new CIN is 3.02% at year 15 and there is no risk of sudden‐onset invasive carcinoma following this procedure. Lasers Surg. Med. 20:461–466, 1997. © 1997 Wiley‐Liss, Inc.