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In vivo intravascular laser photodynamic therapy in rabbit atherosclerotic lesions using a lateral direction fiber
Author(s) -
Katoh Tomitsugu,
Asahara Takayuki,
Naitoh Yuuichi,
Nakajima Hitoshi,
Usui Mikio,
Rakue Hiroyuki,
Amemiya Tadashi,
Miyagi Manabu,
Ibukiyama Chiharu
Publication year - 1997
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/(sici)1096-9101(1997)20:4<373::aid-lsm2>3.0.co;2-n
Subject(s) - hematoporphyrin , photodynamic therapy , in vivo , group b , medicine , group a , pathology , laser therapy , urology , chemistry , nuclear medicine , laser , surgery , biology , optics , microbiology and biotechnology , organic chemistry , physics
Background and Objective This study was performed to evaluate the possibility of inducing regression of atherosclerotic foci by photodynamic therapy (PDT) using hematoporphyrin derivative (HpD). Study Design/Materials and Methods: Atherosclerotic rabbits were divided into four groups. Groups A (n = 6) and C (n = 6) were given 5 mg/kg of HpD intravenously; Groups B (n = 4) and D (n = 4) were not. Twenty‐four hours after HpD administration, the aortae of groups A and B were exposed to 200 mw output argon dye laser beam at 630 nm for 10 minutes; groups C and D were exposed to 400 mw for 5 minutes. Three rabbits from groups A and C and two rabbits from groups B and D were sacrificed immediately after laser photoradiation, being named gorups A 0, C 0 and groups B 0, D 0, respectively. Groups A 7, C7 and Groups B 7, D 7 were sacrificed 7 days after the photoradiation. Results In groups A 7 and C 7, most intimal cells and endothelial cells had become necrotic and disappeared, and a loss of intima was observed. No such changes were found in groups B 7, D 7. Conclusion The above data suggest that PDT caused effective regression of the atherosclerotic lesions. Lasers Surg. Med. 20: 373–381, 1997. © 1997 Wiley‐Liss, Inc.