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Low power laser irradiation reduces ischemic damage in hippocampal slices in vitro
Author(s) -
Iwase Tatsuo,
Hori Nobuaki,
Morioka Toshio,
Carpenter David O.
Publication year - 1996
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/(sici)1096-9101(1996)19:4<465::aid-lsm13>3.0.co;2-1
Subject(s) - hippocampal formation , irradiation , in vitro , laser , ischemia , chemistry , biophysics , neuroscience , biomedical engineering , medicine , biology , optics , cardiology , physics , biochemistry , nuclear physics
Background and Objective Low power laser irradiation has been reported to reduce injury, promote regeneration, and produce analgesia. While the mechanism is unknown, one hypothesis is that light produces free radicals, which have a beneficial effect at low concentrations. Study Design/Materials and Methods We have investigated the effects of low power laser irradiation on the loss of electrical excitability of hippocampal brain slices after a transient exposure to a perfusion medium lacking oxygen and containing reduced glucose concentrations. Injury in this system is known to result at least in part from free radical production. Results Low power laser irradiation increased the time required for loss of excitability and increased recovery from the ischemic injury. Conclusions Low power laser irradiation has acute protective effects against ischemic damage in brain slices. © 1996 Wiley‐Liss, Inc.