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No prognostic significance of p53 expression in esophageal squamous cell carcinoma
Author(s) -
Kanamoto Akira,
Kato Hoichi,
Tachimori Yuji,
Watanabe Hiroshi,
Nakanishi Yukihiro,
Kondo Hitoshi,
Yamaguchi Hajime,
Gotoda Takuji,
Muro Kei,
Matsumura Yasuhiro
Publication year - 1999
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199910)72:2<94::aid-jso10>3.0.co;2-9
Subject(s) - medicine , immunohistochemistry , stage (stratigraphy) , esophageal cancer , carcinoma , oncology , grading (engineering) , population , pathology , univariate analysis , cancer , multivariate analysis , biology , paleontology , ecology , environmental health
Background and Objectives It is generally accepted that the overexpression of p53 protein is associated with poor prognosis in breast, colorectal, and other types of cancer. However, the prognostic significance of p53 aberrations in esophageal squamous cell carcinoma has yet to be determined. We attempted to analyze the relationship between p53 expression and the clinicopathologic features of esophageal squamous cell carcinoma by reviewing the medical records of a large patient population. Our study of esophageal squamous cell carcinoma involves the largest patient population to date. Methods p53 expression in formalin‐fixed, paraffin‐embedded samples of 239 patients with primary esophageal squamous cell carcinoma (TNM stage I:79 cases, stage II: 82 cases, stage III: 78 cases), who underwent esophageal resection without additional treatment, were analyzed by immunohistochemical staining using a polyclonal antibody, RSP53. The relationships between p53 immunoreactivity and prognostic factors were determined by the χ 2 test, and the prognostic impact of p53 protein expression was analyzed by univariate and multivariate survival analyses. Results In 115 (48.1%) of 239 esophageal tumors, nuclear immunoreactivity for the p53 protein was detected. The expression of the p53 protein did not correlate with sex, age, histological grading, lymph node metastasis, vascular invasion, or TNM stage. Similiarly, p53 expression did not correlate with prognosis in univariate and multivarite survival analysis. Conclusions The expression of the p53 gene product had no impact on the prognosis of esophageal squamous cell carcinoma. J. Surg. Oncol. 1999;72:94–98. © 1999 Wiley‐Liss, Inc.