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Use of subatmospheric pressure to prevent doxorubicin extravasation ulcers in a swine model
Author(s) -
Morykwas Michael J.,
Kennedy Amanda,
Argenta James P.,
Argenta Louis C.
Publication year - 1999
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199909)72:1<14::aid-jso4>3.0.co;2-3
Subject(s) - extravasation , medicine , doxorubicin , doxorubicin hydrochloride , anesthesia , animal model , surgery , chemotherapy , pathology
Application of subatmospheric pressure to sites injected with doxorubicin prevented ulcer formation in treated sites (0 ulcers/16 sites) compared to control wounds (10 ulcers/16 sites) in a pig model. Background and Objectives Extravasation of doxorubicin hydrochloride (Adriamycin) frequently causes chronic ulcers, which usually progress and expose underlying structures such as tendons and bone. The exact mechanism of action that causes cell death and the chronic ulcers is unknown. Methods Eight sites were injected intradermally with doxorubicin on each of 4 pigs. Four sites on each animal served as untreated controls. The remaining four sites were exposed to 125 mm Hg subatmospheric pressure applied 1 h after injection. The sites were observed on a three times per week schedule. Sites that did not develop ulcers were re‐injected up to a total of four injections. The animals were observed for 5 weeks. Results Ten of sixteen control sites developed ulcers. No subatmospheric pressure treated sites developed ulcers. The incidence of ulcer formation was significantly less for treated wounds compared to control wounds at P < 0.001 by Fisher's exact test. Conclusions This physical modality appears to successfully prevent ulcer formation after doxorubicin injection. J. Surg. Oncol. 1999;72:14–17. © 1999 Wiley‐Liss, Inc.