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Prophylactic and therapeutic use of antibiotics in pelvic surgery
Author(s) -
Price Shaun A.,
Polk Hiram C.
Publication year - 1999
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199908)71:4<261::aid-jso12>3.0.co;2-x
Subject(s) - medicine , antibiotics , intensive care medicine , drug , antimicrobial , prophylactic antibiotic , surgery , antibiotic prophylaxis , pharmacology , chemistry , organic chemistry , microbiology and biotechnology , biology
The abiding principles of antibiotic use in the surgical patient vary in the complicated pelvic surgery setting only in that some microbes likely to be encountered warrant minor variation in drug choice. Very early antibiotic administration, relatively large doses, and prompt association when the reason for therapy has been accomplished, are the keystones for treatment. Tissue levels of antimicrobial activity are the uniform therapeutic goal. We also prefer consistent selection of drugs known to be safe and believe that continuous infusion may enhance the overall protective effect. Preservation of normal host defenses enhances the action of all antibiotics. J. Surg. Oncol. 1999;71:261–268. © 1999 Wiley‐Liss, Inc.