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Prognostic impact of cyclin‐dependent kinase inhibitor p27 kip1 in node‐positive breast cancer
Author(s) -
Tsuchiya Atsuo,
Zhang Guo Jun,
Kanno Masahiko
Publication year - 1999
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199904)70:4<230::aid-jso6>3.0.co;2-i
Subject(s) - medicine , oncology , breast cancer , kinase , cyclin dependent kinase 4 , cancer , cyclin dependent kinase , cancer research , cyclin dependent kinase 2 , cell cycle , microbiology and biotechnology , biology
Background and Objectives p27 kip1 (p27) plays an important role as a negative regulator of cell cycle‐dependent kinase activity during progression of the cell cycle. The most important prognosticator of breast cancer is nodal status, and the aim of this study was to determine the prognostic implication of p27 in breast cancer patients with lymph node metastases. Methods Immunohistochemical staining for p27 was performed on tissues from 102 patients with node‐positive breast cancer. Results A nuclear staining over 50% was defined as high expression. High expression of p27 was shown in 59 patients (57.8%). A significant correlation was found between high p27 and positive estrogen receptor status, but there was no correlation between p27 staining and age, menopausal status, nodal status, or tumor size. Low expression of p27 was significantly associated with shorter survival. A multivariate analysis also showed that the only independent variable was p27. Conclusions The results indicated that low expression of p27 was an independent factor associated with poor prognosis. Therefore, p27 can be an important tool in making therapeutic decisions. J. Surg. Oncol. 1999;70:230–234. © 1999 Wiley‐Liss, Inc.