Premium
Immunohistochemical expression of cytokeratins in intrahepatic cholangiocarcinoma and metastatic adenocarcinoma of the liver
Author(s) -
Sasaki Atsushi,
Kawano Katsunori,
Aramaki Masanori,
Nakashima Kimihiro,
Yoshida Takanori,
Kitano Seigo
Publication year - 1999
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199902)70:2<103::aid-jso8>3.0.co;2-h
Subject(s) - medicine , intrahepatic cholangiocarcinoma , immunohistochemistry , pathology , adenocarcinoma , metastatic adenocarcinoma , cytokeratin , cancer
Background and Objectives This study was designed to identify a difference in immunostaining that might help to distinguish between primary and metastatic liver neoplasms. Methods We examined immunohistochemical expression of cytokeratins (CKs) 7, 8, 19, and 20 in 12 intrahepatic cholangiocarcinomas (ICCs; 9 of the mass‐forming and 3 of the infiltrating type), 25 metastatic colorectal carcinomas (MCCs), and 7 metastatic gastric carcinomas (MGCs) of the liver. Results CKs 7 and 19 were expressed in all ICCs of infiltrating type, while each was seen in 7/9 (77.8%) of mass‐forming type. CK 7‐positive/CK 20‐negative was seen in 9/12 (75.0%) of ICCs and in none of the 25 MCCs, while CK 7‐negative/CK 20‐positive was seen in 1/12 (8.3%) of ICCs and 20/25 (80.0%) of MCCs. No differences were observed between MGCs and ICCs. Conclusions These results suggest that immunohistochemical staining for both CKs 7 and 20 is useful for the differential diagnosis of ICCs and MCCs, whereas phenotypic expression of CKs appears to be different between mass‐forming and infiltrating types of ICCs. J. Surg. Oncol. 1999;70:103–108. © 1999 Wiley‐Liss, Inc.