Premium
Different distributions of immunoreactive S100‐α and S100‐β protein expression in human breast cancer
Author(s) -
Funahashi Hiroomi,
Koshikawa Takashi,
Ichihara Shu,
Ohike Ekoh,
Katoh Kanehusa
Publication year - 1998
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199805)68:1<25::aid-jso6>3.0.co;2-n
Subject(s) - s100 protein , immunohistochemistry , medicine , breast cancer , pathology , staining , breast carcinoma , carcinoma , cancer
Background and Objectives: Although the localization of S100 protein in breast carcinoma has previously been studied, the immunohistochemical expression of the S100‐α and ‐β subunits has not been examined. Methods Immunohistochemical staining for S100‐α and S100‐β proteins was performed on 72 benign breast lesions and 72 infiltrating ductal carcinoma of the breast. Noncross‐reactive anti‐S100‐α and anti‐S100‐β antibodies purified by affinity chromatography were used in the studies. Results More than 30% of the epithelial cells comprising all the benign lesions were either S100‐α or S100‐β positive. In breast carcinoma cases, however, >30% of malignant cells were S100‐α positive in 70/72 cases (97.2%), whereas the number of S100‐β positive cells exceeded 30% in only 3/72 cases (4.0%). Conclusions Immunohistochemical staining for S100‐α and S100‐β proteins may help to differentiate benign proliferative breast lesions from breast cancers in difficult cases. J. Surg. Oncol. 1998;68:25–29. © 1998 Wiley‐Liss, Inc.