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An evaluation of the markers p53 and Ki‐67 for their predictive value in prostate cancer
Author(s) -
Uzoaru Ike,
Rubenstein Marvin,
Mirochnik Yelena,
Slobodskoy Leonid,
Shaw Michael,
Guinan Patrick
Publication year - 1998
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199801)67:1<33::aid-jso7>3.0.co;2-n
Subject(s) - medicine , prostate cancer , stage (stratigraphy) , oncology , prostate , cancer , ki 67 , predictive value , analysis of variance , survival analysis , pathology , immunohistochemistry , biology , paleontology
Background and Objectives p53 and Ki‐67 are but two markers being evaluated for their predictive value in prostate cancer. The purpose of this study was to compare p53 and Ki‐67 with age, stage, Gleason score, and ploidy for their prognostic abilities in prostate cancer. Methods Prostate cancer specimens from 134 patients were immunohistochemically stained for p53 and Ki‐67 expression and differences evaluated by SPSS analysis of variance (ANOVA) methods. The dependent variable was patient survival and the independent variables were age, stage, Gleason score, and ploidy. Results In decreasing order of prediction of survival were stage ( P < 0.001), Gleason score ( P < 0.001), age ( P = 0.1869), Ki‐67 ( P = 0.2284), p53 ( P = 0.4282) and ploidy ( P = 0.8141). Conclusion It is concluded that stage and Gleason score are significant predictors of survival while p53, Ki‐67, age and ploidy are not. J. Surg. Oncol. 1998;67:33–37. ©1998 Wiley‐Liss, Inc.