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Radical oncologic surgery affects the circulatory levels of interleukin 10
Author(s) -
Gianotti Luca,
Fortis Claudio,
Braga Marco,
Gentilini Oreste,
Vignali Andrea,
Di Carlo Valerio
Publication year - 1997
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199712)66:4<244::aid-jso4>3.0.co;2-b
Subject(s) - medicine , cancer , gastroenterology , laparotomy , surgery , adenocarcinoma , pancreatic cancer , radical surgery , urology
Background and Objective Interleukin 10 (IL‐10) has been shown to be elevated in the plasma of cancer‐bearing patients. The source of systemic IL‐10 may be the tumor microenvironment. We therefore tried to evaluate if ablative surgery for gastrointestinal cancer could affect the levels of circulating IL‐10. Methods Plasma IL‐10 concentration was measured in 45 patients with adenocarcinoma of the gastrointestinal tract. Forty healthy subjects, 15 women undergoing hysterectomy for uterine fibroma, and 15 patients undergoing palliative operation for pancreatic cancer were used as control groups. Plasma IL‐10 was assessed 1 day before surgery (baseline) and 1, 4, and 8 days after operation. Results The baseline concentration of IL‐10 was significantly higher in cancer patients than in healthy subjects and in women with fibroma (8.6 ng/mL, 2.1 and 1.8 respectively; P = 0.015). After radical surgery, the IL‐10 levels significantly dropped in cancer patients (from 8.6 ng/mL to 3.8; P = 0.024), whereas in subjects undergoing palliative operation, the concentration remained elevated (8.5 ng/mL baseline versus 7.9 on day +1). Conclusions The origin of circulating IL‐10 may be the tumor micro‐environment. J. Surg. Oncol. 1997;66:244–247. © 1997 Wiley‐Liss, Inc.