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Patterns of failure and long‐term results in high‐risk resected gastric cancer treated with postoperative radiotherapy with or without intraoperative electron boost
Author(s) -
MartínezMonge Rafael,
Calvo Felipe A.,
Azinovic Ignacio,
Aristu Jose Javier,
Hernández Jose Luis,
Pardo Fernando,
Fernández Pablo,
GarcíaFoncillas Jesús,
AlvarezCienfuegos Javier
Publication year - 1997
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199709)66:1<24::aid-jso6>3.0.co;2-p
Subject(s) - medicine , radiation therapy , cancer , adverse effect , lymph node , surgery , retrospective cohort study , pathological
Background To evaluate the possible role of adjuvant radiotherapy in the management of high‐risk resected gastric carcinoma. Methods From 1982 to 1993, 62 patients surgically resected of a primary gastric cancer with adverse pathological features (serosal and/or regional lymph node involvement) were treated with postoperative radiotherapy with (Group I) or without (Group II) intraoperative electron boost to the surgical bed and coeliac axis (IORT). Results After a median follow‐up of 75.6 months (range 4–120+) for IORT patients and 91.2 months (range 6–149+) for non‐IORT patients, overall relapse rates for Group I and Group II patients were 44.5% and 48.6% and local‐regional relapse rates were 11.1% and 20%, respectively. Actuarial survival rates projected at the maximum follow‐up were 41% and 38% in Groups I and II, respectively. Conclusions This retrospective analysis suggests a beneficial effect of adjuvant external radiotherapy in promoting local‐regional control in high‐risk resected gastric cancer. J. Surg. Oncol. 1997;66:24–29. © 1997 Wiley‐Liss, Inc.