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Proliferating cell nuclear antigen expression in the gallbladder with pancreaticobiliary maljunction
Author(s) -
Isozaki Hiroshi,
Okajima Kunio,
Hara Hitoshi,
Sako Shozo,
Mabuchi Hideaki
Publication year - 1997
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199705)65:1<46::aid-jso9>3.0.co;2-o
Subject(s) - gallbladder , proliferating cell nuclear antigen , medicine , immunohistochemistry , gallbladder cancer , gastroenterology , pathology , histogenesis , epithelium
Background and Objective: To clarify the histogenesis of cancer of the gallbladder of the patients with pancreaticobiliary maljunction (PBMJ), the proliferating cell activity of the epithelium of gallbladder was examined. Methods A total of 21 patients with pancreaticobiliary maljunction [8 with gallbladder cancer (MCA group) and 13 without cancer (M group)] were studied using immunohistochemical staining with a monoclonal antibody to the proliferating cell nuclear antigen (PCNA). The 23 gallbladder cancer patients without PBMJ (CA group) and 10 patients with normal gallbladders (N group) were also examined as controls. Results The PCNA‐positive rates of non‐cancerous epithelium of the gallbladder in patients with PBMJ (14.2% in MCA group and 11.6% in M group) were significantly higher than those without PBMJ (3.9% in CA group and 1.5% in N group). Conclusion The high proliferating cell activity of epithelium of the gallbladder may be an explanation for the high incidence of gallbladder cancer in patients with pancreaticobiliary maljunction. J. Surg. Oncol. 1997;65:46‐49. © 1997 Wiley‐Liss, Inc.