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Advantage of surgery and adjuvant chemotherapy in the treatment of primary gastrointestinal lymphoma
Author(s) -
Lin Kevin M.,
Penney David G.,
Mahmoud Ahmed,
Chae Won,
Kolachalam Ramachandra B.,
Young Shun C.
Publication year - 1997
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199703)64:3<237::aid-jso11>3.0.co;2-1
Subject(s) - medicine , chemotherapy , surgery , lymphoma , adjuvant chemotherapy , adjuvant , stage (stratigraphy) , cancer , paleontology , breast cancer , biology
Background Surgery has been the mainstay of treatment for gastrointestinal (GI) lymphoma. The role of adjuvant chemotherapy to surgery has not been clearly elucidated. Methods The review covered 100 patients who were diagnosed with primary GI lymphoma and treated from 1980 to 1993 at Providence Hospital (Southfield, MI), and Hartford and St. Francis Hospitals (Hartford, CT) with a median follow‐up of 5 years. Forty‐two patients were treated with surgery alone; 31 patients with surgery and adjuvant chemotherapy; 23 patients with primary chemotherapy, and 4 patients received no treatment. Results The 5‐year actuarial survival based on the above treatments calculated by life‐table analysis were 57%, 76%, 58%, and 0%, respectively. This series showed that surgery with adjuvant chemotherapy significantly improved the 5‐year actuarial survival of patients with primary GI Lymphoma and that primary chemotherapy showed comparable survival to surgery alone. There was no difference in prognosis when comparing patients with different stage, grade, or location of disease in the GI tract. Conclusions We recommend surgery when feasible with adjuvant chemotherapy as the mainstay of treatment for primary GI lymphoma. However, if a patient presents with comorbid factors, primary chemotherapy offers an effective alternative. J. Surg. Oncol. 64:237–241, 1997 © 1997 Wiley‐Liss, Inc.