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Morphologic pattern of tenascin as a diagnostic biomarker in colon cancer
Author(s) -
Iskaros Basem F.,
Tanaka Kathryn E.,
Hu Xiaoping,
Kadish Anna S.,
Steinberg Jacob J.
Publication year - 1997
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199702)64:2<98::aid-jso2>3.0.co;2-j
Subject(s) - immunohistochemistry , medicine , colorectal cancer , tenascin , tenascin c , pathology , proportional hazards model , stage (stratigraphy) , cancer , biomarker , hazard ratio , oncology , biology , extracellular matrix , paleontology , confidence interval , biochemistry , fibronectin , microbiology and biotechnology
Background Immunohistochemical methods were used to study the pattern of expression of tenascin (TN) in invasive colon cancer and its relation to prognosis. Methods Sixty patients (29 males, 31 females) with a mean age of 77 years were studied. TN expression was evaluated by immunohistochemistry using paraffin‐embedded tissue sections, TN expression levels were correlated with patient age, tumor stage, and survival. Results TN positivity varied from trace to 4+. Staining patterns were as follows: in well‐differentiated cancer, TN fibers form thick bands around invading tumor glands. In poorly differentiated cancer, TN fibers had an interstitial pattern surrounding individual tumor cells. Using Cox's proportional hazard regression method, survival was significantly related to TN score ( P < 0.0001) and stage of disease ( P < 0.05). No significant relationship was found between survival and age ( P = 0.375). Conclusion Patients with more TN expression had better long‐term survival than patients with no or weak TN expression. Pathologic and clinical entities in colon cancer have distinct immunohistochemical TN matrix patterns that may correlate with predictive value and long‐term survival. J. Surg. Oncol. 64:98–101. © 1997 Wiley‐Liss, Inc.