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Histologic trends in thyroid cancer 1969–1993: A clinico‐pathologic analysis of the relative proportion of anaplastic carcinoma of the thyroid
Author(s) -
Agrawal Shefali,
Rao Raja S.,
Parikh Deepak M.,
Parikh Hemen K.,
Borges Anita M.,
Sampat Mridula B.
Publication year - 1996
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199612)63:4<251::aid-jso7>3.0.co;2-b
Subject(s) - anaplastic carcinoma , medicine , thyroid , medullary carcinoma , pathology , thyroid carcinoma , medullary cavity , anaplastic thyroid cancer , carcinoma , thyroid cancer , histology , oncology
Background It was observed that new presentations of anaplastic carcinoma of the thyroid had become infrequent in the last two decades. Methods All cases of thyroid cancer seen at our centre between 1969–1993 (n = 2921) were classified as papillary 49%, follicular 34%, medullary 7.5%, anaplastic 4.7%, and other 4.8%. The total number of thyroid cancers show a 3.5‐fold rise. Results The differentiated thyroid cancers show a significant rising trend as against the relative proportion of anaplastic carcinoma, which shows a significant decline ( P = 0.002). Clinicopathologic data on 124 patients of anaplastic carcinoma revealed 50% patients had either long‐standing goitres, previous thyroid abnormalities, or associated differentiated thyroid carcinoma on histology. Conclusions The decline in the relative proportion of anaplastic carcinoma may in part be explained by the clinicopathologic findings or it may be attributed to histological reclassification. © 1996 Wiley‐Liss, Inc.