Premium
Angiogenesis in follicular tumors of the thyroid
Author(s) -
Segal Karl,
Shpitzer Thomas,
Feinmesser Meora,
Stern Yoram,
Feinmesser Raphael
Publication year - 1996
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199610)63:2<95::aid-jso5>3.0.co;2-j
Subject(s) - medicine , follicular phase , vascularity , pathology , thyroid , immunohistochemistry , stain , angiogenesis , follicular carcinoma , adenoma , thyroid carcinoma , staining , papillary carcinoma
Background Experimental evidence suggests that tumor growth beyond a certain size and tumor ability to metastasize depend on the degree to which the tumor can stimulate an angiogenic response. Methods Fifteen thyroid specimens of microinvasive follicular carcinoma were examined for vascularization by immunohistochemical stain with antifactor VIII antibodies and compared with an equal number of follicular adenomas. Results Pleomorphic areas in the histological specimens of follicular carcinomas had a higher rate of vascularization as did areas of tumor adjacent to or penetrating the capsule. These features were not noted in follicular adenomas. Conclusions Our findings indicate that vascularity may play a role in extracapsular extension and tumor aggression in follicular thyroid carcinomas. © 1996 Wiley‐Liss, Inc.